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Neisseria meningitidis virulence factors

Neisseria meningitidis: Biology, Microbiology, and

Neisseria meningitidis factor H-binding protein fHbp: a

  1. It is assumed that factors such as production of an IgA1-protease or the ability to attach to the nasopharyngeal epithelial cells contribute to the virulence of the bacteria. The true role of the lipopolysaccharide for the virulence is not clear, but this substance is obviously of great importance in the pathogenesis of the disease caused by virulent strains
  2. Neisseria meningitidis express numerous virulence factors that enable it to interact with diverse microenvironments within the host, during both asymptomatic nasopharyngeal colonization and invasive disease. Many of these interactions involve bacterial or host glycans
  3. Neisseria meningitidis Virulence factors -Meningococcal endotoxin -Capsule -IgA protease -Pili -Outer Membrane Proteins (OMP
  4. The main virulence factor expressed by all extracellular pathogens is a capsule that prevents bacterial phagocytosis or complement-mediated lysis.4,7-12Once inside the cerebrospinal fluid (CSF), bacterial multiplication is thought to be uncontrolled, due to the local deficiency in complement and immunoglobulins, despite the influx of polymorphonuclear leukocytes induced by the local inflammatory response
  5. Neisseria meningitidis, often referred to as meningococcus, is a Gram-negative bacterium that can cause meningitis and other forms of meningococcal disease such as meningococcemia, a life-threatening sepsis. The bacterium is referred to as a coccus because it is round, and more specifically, a diplococcus because of its tendency to form pairs
  6. Since the initial discovery of fHBP, a tremendous amount of work has accumulated on the diversity, structure, and regulation of this important protein. fHBP has proved to be a virulence factor for N. meningitidis and a target for functional bactericidal antibodies. fHBP is critical for survival of meningococci in the human host, as it is responsible for the primary interaction with human factor H (fH)
  7. us subdomain (PILB-MsrB), and the fused subdomain (PILB-MsrA/MsrB) of N. meningitidis were produced as folded entities

To probe mechanisms that govern the functioning of Neisseria meningitidis and Brucella abortus SODs, we used X-ray structures, enzymology, modeling, and murine infection experiments. We identified virulence determinants common to the two homologs, assembly differences, and a unique metal reservoir within meningococcal SOD that stabilizes the enzyme and may provide a safeguard against copper toxicity Neisseria meningitidis N. meningitidis (the meningococcus) is a Gram-negative bacterium, and a major causative agent of bacterial meningitis and severe sepsis. Meningococcal infections are a leading cause of morbidity and mortality worldwide, therefore understanding their molecular biology is crucial to develop therapeutics such as vaccines One of the differentially expressed proteins, GdhA, was identified as an essential virulence factor for establishment of sepsis in an animal model, studied earlier. These results show that in N. meningitidis Hfq is involved in the regulation of a variety of components contributing to the survival and establishment of meningococcal disease Keywords: virulence factors, Neisseria meningitidis, metals, exporter, efflux Citation: Guilhen C, Taha M-K and Veyrier FJ (2013) Role of transition metal exporters in virulence: the example of Neisseria meningitidis

Fig. 1: Overview of Neisseria meningitidistransmission, carriage state, invasion and virulence factors of the meningococcal outer membrane. a| Transmission occurs through contact with respiratory.. Infection with Neisseria meningitidis can produce a variety of clinical manifestations, ranging from transient fever and bacteremia to fulminant disease with death ensuing within hours of the onset of clinical symptoms. N. meningitidis is a common cause of community-acquired bacterial meningitis in both children and adults Meningococci have 3 important virulence factors, [ 13] as follows: Polysaccharide capsule - Individuals with immunity against meningococcal infections have bactericidal antibodies against cell wall.. Gram-negative sepsis is a life-threatening complication of these events. This review discusses the virulence factors of common Gram-negative bacteria causing human sepsis with a focus on Neisseria meningitidis. Adherence, motility, colonization and cell entry involve bacterial pili, flagella and outer membrane proteins

virulence factors; Invasive meningococcal disease caused by Neisseria meningitidis is one of the leading causes of death from infectious diseases globally, with a case-fatality rate of about 10% even with optimal treatment conditions . The normal habitat of the bacterium is the human oropharynx Author Summary Neisseria meningitidis (Nm) is an exclusively human pathogen and a leading cause of bacterial meningitis and septicemia worldwide. Characterization of the bacterial transcriptome during host-pathogen interactions is a fundamental step for understanding the infectious processes of bacterial pathogens. Despite the severity of meningococcal sepsis, little is known about how Nm. Neisseria meningitidis (the meningococcus) is a fastidious Gram-negative diplococcus that colonizes and invades only man. In genetic terms, its closest relative is the gonococcus, Neisseria gonorrhoeae. The entire genetic sequences of a serogroup A and a serogroup B meningococcus have been published Introduction. The primary purpose of this page is to provide illustrations of characteristics of N. meningitidis that may aid in differentiating between this, and other, Neisseria species that produce acid from glucose and maltose.. This page is not intended to be a definitive discussion of N. meningitidis infections but to provide information relating to the accurate identification of N. Meningococcus, an obligate human bacterial pathogen, remains a worldwide and devastating cause of epidemic meningitis and sepsis. However, advances have been made in our understanding of meningococcal biology and pathogenesis, global epidemiology, transmission and carriage, host susceptibility, pathophysiology, and clinical presentations. Approaches to diagnosis, treatment, and.

Thirteen Neisseria meningitidis serogroups have been described on the basis of serologic differences of the capsule; of these 13 serogroups, 6 (A, B, C, W, X, Y) cause invasive meningococcal disease. The polysaccharide capsule is a key virulence determinant, and for serogroups A, C, W, and Y, it forms the basis of polysaccharide conjugate vaccines The N. meningitidis capsule is a well-recognized and important virulence factor; it surrounds and provides protection to the bacterial cell [Reference Stephens 3]. The capsule polysaccharides vary in chemical structure, and provide a basis for serogroup classification of N. meningitidis

Neisseria The genus Neisseria contains two important human pathogens, N. gonorrhoeae and N. meningitidis. N. gonorrhoeae causes gonorrhea, and N. meningitidis is the cause of meningococcal meningitis. Neisseria gonorrhoeae infections are acquired by sexual contact and usually affect the mucous membranes of the urethra in males and the endocervix and urethra in females N. meningitidis utilize a variety of virulence factors to facilitate survival and proliferation in the host reservoir.. Capsules. The absence or presence of encapsulated N. meningitidis is highly dependent on the origin of sample. When isolated from carriers, the bacteria may be either capsulate or acapsulate, while samples isolated from cerebrospinal fluid or the bloodstream are consistently. Metabolism and virulence in Neisseria meningitidis. A longstanding question in infection biology addresses the genetic basis for invasive behavior in commensal pathogens. A prime example for such a pathogen is Neisseria meningitidis. On the one hand it is a harmless commensal bacterium exquisitely adapted to humans, and on the other hand it. Neisseria meningitidis is non motile and non spore forming. N. meningitidis has a polysaccharide capsule that surrounds the outer membrane of the bacterium and protects against immune mechanism of human. It is considered to be an essential virulence factor for the bacteria. Based on the capsular polysaccharide, nine serogroups of Neisseria.

Meningococcal disease refers to any illness caused by bacteria called Neisseria meningitidis, also known as meningococcus [muh-ning-goh-KOK-us].These illnesses are often severe and can be deadly. They include infections of the lining of the brain and spinal cord (meningitis) and bloodstream infections (bacteremia or septicemia) Virulence factors that enable the meningococcus to evade the immune system include the endotoxin, pili and the capsule polysaccharide. The capsule antigens are also used as targets for vaccines. Based on capsular polysaccharides, Neisseria meningitidis can be classified into 12 serogroups , 6 of which are responsible for global epidemics.

virulence is related to both capsule expression, expression of other surface structures, and underlying genotype (fi gures 2 and 3), and strain virulence can be estimated by the number of cases of invasive meningococcal disease that arises per acquisition event. Genome sequences for N meningitidis strains MC5 Identification and Characterization of Neisseria meningitidis. N. meningitidis are gram-negative, coffee-bean shaped diplococci that may occur intracellularly or extracellularly in PMN leukocytes. N. meningitidis is a fastidious organism, which grows best at 35-37°C with ~5% CO 2 (or in a candle-jar). It can grow on both a blood agar plate. Neisseria meningitidis is the causative agent of invasive meningococcal disease and the polysaccharide capsule is one of its major virulence factors. Biosynthesis of the meningococcal capsule is controlled by an RNA thermosensor (RNAT) in the 5′-untranslated region (5′-UTR) of the cssA gene. The function of the RNAT depends on an 8-bp tandem repeat configuration

This review summates the current basis of numerous anti-virulence strategies being explored for N. gonorrhoeae. AB - While antimicrobial resistance (AMR) is seen in both Neisseria gonorrhoeae and Neisseria meningitidis, the former has become resistant to commonly available over-the-counter antibiotic treatments Characterization of Neisseria meningitidis isolates that do not express the virulence factor and vaccine antigen factor H binding protein Jay Lucidarme , Lionel Tan, Rachel M. Exley, Jamie Findlow, Raymond Borrow , Christoph M. Tan Neisseria gonorrhoeae and Neisseria meningitidis are Gram-negative diplococci.N. gonorrhoeae is the causative agent of gonorrhoea and is transmitted via sexual contact.N. meningitidis is transmitted via respiratory droplets leading to colonization of the nasopharynx and can cause meningitis and septicemia.. This important reference volume provides research scientists, advanced students. Teenagers are important carriers of Neisseria meningitidis, which is a leading cause of invasive meningococcal disease.In China, the carriage rate and risk factors among teenagers are unclear. The present study presents a retrospective analysis of epidemiological data for N. meningitidis carriage from 2013 to 2017 in Suizhou city, China. The carriage rates were 3.26%, 2.22%, 3.33%, 3.53% and 9. Figure 1. Neisseria meningitidis scanning EM. Neisseria meningitidis, also known as meningococcus, is a parasitic, aerobic, Gram-negative, nonmotile, coccal bacterium that is responsible for causing meningitis and meningococcal septicemia, a serious condition that causes hemorrhaging of the skin.Symptoms of meningitis were first noted in 1805 but it was not isolated until 1887 by Weichselbaum

Commonly referred to as the meningococcus. Neisseria meningitidis is a Gram-negative diplococcus, typically flattened where the cocci meet. Oxidase positive. Aerobic. There are 13 serogroups of meningococci. Serogroups B and C commonly cause meningitis and meningococcemia in developed countries; serogroups Y and W135 typically cause pneumonia Thirteen Neisseria meningitidis serogroups have been described on the basis of serologic differences of the capsule; of these 13 serogroups, 6 (A, B, C, W, X, Y) cause invasive meningococcal disease. The polysaccharide capsule is a key virulence determinant, and for serogroups A, C, W, and Y, it forms the basis of polysaccharide conjugate vaccines @article{osti_1224775, title = {Structural, functional and immunogenic insights on Cu,Zn superoxide dismutase pathogenic virulence factors from Neisseria meningitidis and Brucella abortus}, author = {Pratt, Ashley J. and DiDonato, Michael and Shin, David S. and Cabelli, Diane E. and Bruns, Cami K. and Belzer, Carol A. and Gorringe, Andrew R. and Langford, Paul R. and Tabatabai, Louisa B. and.

Characterization of Neisseria meningitidis isolates that do not express the virulence factor and vaccine antigen factor H binding protein. Jay Lucidarme Vaccine Evaluation Unit, Health Protection Agency, North West Regional Laboratory, P.O. Box 209, Clinical Sciences Building II, Manchester Royal Infirmary, Manchester M13 9WZ, United Kingdom Neisseria meningitidis infection is a major life-threatening disease worldwide. to closely related species and to identify virulence or pathogenesis-related factors, such as genes involved in.

Neisseria

McNeil, L. K. et al. Role of factor H binding protein in Neisseria meningitidis virulence and its potential as a vaccine candidate to broadly protect against meningococcal disease. Microbiol. Mol Introduction. Neisseria meningitidis is a commensal to the human nasopharynx ().Rarely, it crosses the mucosal barrier to cause invasive meningococcal disease, which can manifest as bacteremia, fulminant septicemia and meningitis ().Meningitis occurs in over 60% of patients with invasive meningococcal disease, dependent on the income level of a country and patient age, and is invariably.

Keywords: virulence factors, Neisseria meningitidis, metals, exporter, efflux INTRODUCTION to call attention to these efflux systems as virulence factors, For decades, it has been known that transition metals played a as they have received less attention than metal importer sys- role in regulating host pathogen relationships (Weinberg, 1971; tems Teenagers are important carriers of Neisseria meningitidis, which is a leading cause of invasive meningococcal disease. In China, the carriage rate and risk factors among teenagers are unclear. The present study presents a retrospective analysis of epidemiological data for N. meningitidis carriage from 2013 to 2017 in Suizhou city, China

Virulence Factors of Meningitis-Causing Bacteria: Enabling

Joseph, B. et al. Virulence evolution of the human pathogen Neisseria meningitidis by recombination in the core and accessory genome. PLOS ONE 6 , e18441 (2011). CAS PubMed PubMed Central Google. Lipooligosaccharide and Polysaccharide Capsule: Virulence Factors of Neisseria meningitidis That Determine Meningococcal Interaction with Human Dendritic Cells Alexandra Unkmeir , 1 Ulrike Kämmerer , 2 Anne Stade , 1 Claudia Hübner , 1 Sabine Haller , 1 Annette Kolb-Mäurer , 1, 3 Matthias Frosch , 1, * and Guido Dietrich 1, priate animal model, most insight in pathogenicity factors of N. meningitidis resulted from in vitro studies with cell cultures, and thus the in vivo relevance for most of these candidate virulence factors still remains to be validated (7). One of the well estab-lished virulence factors in N. meningitidis is the polysaccharid A very large CGH study was performed on one Neisseria cinerea, two N. lactamica, two N. gonorrhoeae and 48 N. meningitidis isolates, with an aim to better understand N. meningitidis genomes and.

Frontiers Metabolism and virulence in Neisseria

Neisseria is a large genus of bacteria that colonize the mucosal surfaces of many animals. Of the 11 species that colonize humans, only two are pathogens, N. meningitidis and N. gonorrhoeae.Most gonococcal infections are asymptomatic and self-resolving, and epidemic strains of the meningococcus may be carried in >95% of a population where systemic disease occurs at <1% prevalence For the most common pathogens causing bacterial meningitis in adults, such as Streptococcus pneumoniae and Neisseria meningitidis, meningeal invasion is related to several virulence factors that allow the bacteria to colonize host mucosal epithelium, invade and survive within the bloodstream, cross the blood-brain barrier, and multiply within.

Nongroupable N. meningitidis lacks capsule production, which is a major virulence factor in causing invasive meningococcal disease. The infant received erythromycin gonococcal ophthalmic prophylaxis according to standard care guidelines and bacitracin/polymyxin ointment for empiric treatment of conjunctivitis and was discharged to home Introduction. The genus Neisseria is a large group of β-Proteobacteria that are obligate symbionts of humans and animals. At least eight species of commensal Neisseria colonize human mucosal surfaces , .These sites are also infected by two pathogenic Neisseria: Neisseria meningitidis, which causes epidemics of meningitis and septicemia, and Neisseria gonorrhoeae, a sexually transmitted bacterium Additionally, Neisseria gonorrhoeae, as well as Neisseria meningitidis and Haemophilus influenzae, are capable of further modifying their LOS in vitro, for example through sialylation (modification with sialic acid residues), and as a result are able to increase their resistance to complement-mediated killing or even down-regulate complement. LOS is a major virulence factor during meningococcal sepsis and meningitis. The severity of meningococcal disease is directly correlated with the levels of endotoxin in the plasma and cerebrospinal fluid . N. meningitidis is the first viable gram-negative bacterium harboring an inactivated lpxA gene, and thu Europe PMC is an archive of life sciences journal literature. Search worldwide, life-sciences literature Searc

Virulence Evolution of the Human Pathogen Neisseria

Neisseria meningitidis is a leading cause of infectious childhood mortality worldwide. Most research efforts have hitherto focused on disease isolates belonging to only a few hypervirulent clonal lineages. However, up to 10% of the healthy human population is temporarily colonized by genetically diverse strains mostly with little or no pathogenic potential Suggestion merge Meningococcemia to Neisseria meningitidis. My proposal is on same basis as for Meningococcal disease (foir which Meningococcal meningitis redirects to it), but I'll split the proposal in case people feel that one merger has different merits from the other. David Ruben Talk 01:31, 15 June 2006 (UTC FOR BACTERIOLOGY FULL LECTURE SERIES FOLLOW THE BELOW LINKSGRAM POSITIVE COCCI : https://www.youtube.com/playlist?list=PL34l4BbhJQ8OlbOB4wx7TUrWrpmiMioX3GRAM..

Lectures 13-14-Neisseria gonorrhoea, N

Virulence factors in meningococci - PubMe

The glycointeractome of serogroup B Neisseria meningitidis

Gram Negative Cocci - Microbiology learning: The &quot;whymicro review Flashcards | Quizlet

Mechanism of meningeal invasion by Neisseria meningitidi

Neisseria meningitidis is a Gram-negative, non-spore forming, non-motile, encapsulated, and non-acid-fast diplococci, which appears in kidney bean shape under the microscope. There are thirteen types (serogroups) of Neisseria meningitidis, nine of which cause invasive diseas The pathogenic bacterium Neisseria meningitidis is an important cause of septicemia and meningitis, especially in childhood1. The establishment and maintenance of bacteremic infection is a pre.

Neisseria meningitidis - Wikipedi

Invasive infections caused by Neisseria meningitidis (meningococci) cause high rates of illness and death worldwide (1-3).Meningococci have frequently caused epidemics in Iceland, a relatively isolated community in the mid-Atlantic (4,5).To more fully understand the phylogeny of meningococcal strains, various typing methods have been used, including serogroup and serotype classifications Cytokine levels did not correlate repertoire of LOS structures, is an important virulence factor with a shift of neutrophil levels in blood samples following chal- involved in multiple steps in the pathogenesis of N. meningitidis lenge (Fig. 7C), since all strains induced comparable influxes of and is a significant contributor to the. Neisseria meningitidis is a leading bacterial cause of sepsis and meningitis globally with dynamic strain distribution over time. Beginning with an epidemic among Hajj pilgrims in 2000, serogroup W (W) sequence type (ST) 11 emerged as a leading cause of epidemic meningitis in the African 'meningitis belt' and endemic cases in South America, Europe, Middle East and China The 2,272,351-base pair genome of Neisseria meningitidis strain MC58 (serogroup B), a causative agent of meningitis and septicemia, contains 2158 predicted coding regions, 1158 (53.7%) of which were assigned a biological role. Three major islands of horizontal DNA transfer were identified; two of these contain genes encoding proteins involved in pathogenicity, and the third island contains.

Role of factor H binding protein in Neisseria meningitidis

Introduction. Neisseria meningitidis or meningococcus (Nm) is a Gram-negative human-exclusive pathogen that asymptomatically colonizes the upper respiratory tract of 10-40% of the world population (Rouphael and Stephens, 2012).In susceptible individuals, Nm infection is a leading cause of purpura fulminans and meningitis. Meningitis is a disease that is still associated with high mortality. Abstract. Neisseria meningitidis (Nm) clonal complex 11 (cc11) lineage is a hypervirulent pathogen responsible for outbreaks of invasive meningococcal disease, including among men who have sex with men, and is increasingly associated with urogenital infections. Recently, clusters of Nm urethritis have emerged primarily among heterosexual males in the United States Lipooligosaccharide and polysaccharide capsule: virulence factors of Neisseria meningitidis that determine meningococcal interaction with human dendritic cells. Infect. Immun. 70 : 2454-2462 Neisseria meningitidis is fastidious and should be grown overnight on horse blood agar from glycerol stocks for a maximum of 16 h before use to ensure minimal mutation rates or downregulation of virulence factors. This may result from the phase variability of some Neisseria genes.N. meningitidis can be cultured successfully in a low‐carbohydrate medium, such as Mueller-Hinton broth (MHB. Meningococcal meningitis is a rare but serious bacterial infection. It causes the membranes that cover the brain and spinal cord to become inflamed. Each year, approximately 1,000 people in the U.

Characterization of the methionine sulfoxide reductase

The modD gene also appears to be Neisseria specific, and has five known alleles: modD1 and modD2 in N. meningitidis, modD3 in N. lactamica, modD4 in Neisseria cinerea and modD5 in Neisseria mucosa 27 Many so-called pathogenic bacteria such as Neisseria meningitidis, Haemophilus influenzae, Staphylococcus aureus and Streptococcus pneumoniae are far more likely to colonize and maintain populations in healthy individuals asymptomatically than to cause disease. Disease is a dead-end for these bacteria: virulence shortens the window of time during which transmission to new hosts can occur. I. Epidemiology of Meningitis Caused by Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumoniae: II. General Considerations A. Record Keeping: III. Collection and Transport of Clinical Specimens A.Collection of Cerebrospinal Fluid (CSF) A1. Lumbar Puncture B. Collection of Blood B1. Precautions B2. Sensitivity of Blood.

A & D Virulence Factors at Russian State University forPPT - Virulence Factors & Features Important in Diseaseneisseria, rickettsia, chlamydias

Neisseria meningitidis was prefixed in 2.5% Glutaraldehyde diluted in PHEM (Pipes, Hepes, EGTA and MgSO 4) buffer at pH 7. The cells were prefixed for 1 hr at room temperature, followed by two washes in PHEM buffer. The samples were applied onto the cover glass (1.5 mm) pre-coated with poly-L-Lysine (Jun 2011). Characterization of Neisseria meningitidis isolates that do not express the virulence factor and vaccine antigen factor H binding protein. Clin Vaccine Immunol. 18:1002-1014. DOI. 2010. Zhang Q; Li Y; Tang CM. (29 Oct 2010). The role of the exopolyphosphatase PPX in avoidance by Neisseria meningitidis of complement-mediated killing. ABSTRACT The identification of factor H binding protein (fHbp)-null invasive meningococcal isolates and the realization that widespread use of fHbp-based vaccines could herald selection of such strains prompted us to characterize novel mechanisms of alternative pathway (AP) inhibition on meningococci. Of seven strains engineered to lack four known AP-inhibiting molecules, capsular. Part of the explanation for this phenomenon is the fact that meningitis due to Neisseria meningitidis tends to strike young, previously well individuals and can progress over a matter of hours to death. Mortality can be very high if the infection is not treated appropriately, and long-term sequelae can be severe even in successfully managed cases

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